Protein Details: Voltage gated sodium channel protein type 10 subunit alpha
Protein ID
ICDB_Pro_0330
Protein Name
Voltage gated sodium channel protein type 10 subunit alpha
Gene Name
Scn10a; Sns
Organism
Onychomys torridus (Southern grasshopper mouse)
Length
1959 amino acids
AlphaFoldDB
AF-P0DMA5-F1-model_v4.pdb
Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
Sequence
MEFPIGSVGTTNFRRFTPESLAEIEKQIAAHGAAKKARAKHGERKGQDEKPRPQLDLKACNQLPRFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATWALWLFSPFNLIRRTAIKVSVHAWFSIFITITILFNCVCMTQNDLPEKIEYAFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIKRSTDPHNAYNFSSQMADNFYIKNGTTEPLLCGNGSDAGHCPSGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATIAEIEAKEKKFQEALEVLQKEQEVLAALGIDTTSLHSHNGSPLAPKNANERKHRIKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRASHSSVFHFRAPSQDVSFPDGITDDGVFHGDHESHRSSLLLARGAGQAGPLPRSPLASSPNPGPGHREEGQLTAPTGELTTGAPEDLALEAAGQKKNFLSAEYLNEPFRAQRAMSVVSIMTSVIEELEESKLRCPPCLINLAQKYLIWECCPKWMKFKMVLFELVTDPFAELTITLCIVVNTIFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNVFDCVIVTVSLLELSIAKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLGEDYGCRKDGTALWNEGQLRWHMCDFFHSFLVIFRILCGEWIENMWVCMQVSEKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARTQAFGQRASQAISSYFSSHCRLRWPKVGSQLGVKPSLTSSKAEHHITADAVNTAVGTSAKPALSGPKEDPRDFITDANVWVSVPIAEGESDLDELEEDIEQNSQSSWREESPKGQQDQLWQIQRCEDHQVPNSPGSGMSSEDLASYLGERWKSEATPQVPAEGVDDTSSSEGSTVDCPDPEEILKKIPELADDLEEPDDCFTEGCTRHCPCCKVSTSKFPWTTGWQVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEQKPRVKSMLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLTSLIAKILDYSDVASLKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCIDTSNNPFSVVNSTIVNNKSECRNQNHTGHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREINSQPQWEDNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDGQSEEKTKILGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIGSLVFSAILKSLESYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVVEEAGIDDMFNFQTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLSNNNTSKGNCGSPTVGIVFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLRWKQEDISATVIQKAYRSYVLQRSLTLSNPLRVPRAEDDDAPLPGEGYVTFMANDSGRLPDKSETTSATSFPPSYDSVTRGLSDRVNISTSNSMHNEDEVTSKEGDSPGPQ
PDB Structures
Ligand Binding
Binding Site
Disease
neuropathic pain
Location
Plays a role in neuropathic pain mechanisms
DOI ID
10.1126/science.1236451